. Author manuscript; available in PMC: 2014 Sep 5.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 Apr 26;32(7):1724–1731. doi: 10.1161/ATVBAHA.112.250464

Table.

Antibodies and Recombinant Cadherin 6 protein Inhibit Platelet Aggregation

	TRAP	TRAP4	ADP	Collagen	Risto
Cdh6 pAb	27%	28%	46%	65%	N/D
Cdh6 mAb	64%	N/D	N/D	78%	72%
Isotype control	124%	100%	120%	94%	100%
Cdh6_IgG	53%	N/D	14%	35%	N/D
P-Cdh_IgG	150%	N/D	175%	133%	N/D

Risto indicates ristocetin; N/D, not done; P-Cdh_IgG, placental cadherin_IgG fusion protein; Cdh6_IgG, cadherin 6_IgG fusion protein; TRAP, thrombin receptor activating peptide.

Aggregation is expressed as a percent of the maximum response obtained with agonist alone. TRAP=SFFLRN, TRAP4=AYPGKF.