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Simvastatin depletion in rat hepatic microsomes (A), 1-hydroxymidazolam formation from midazolam in rat hepatic microsomes (B) and the corresponding Eadie-Hofstee plots (C), and uptake of simvastatin (D) by hepatocytes of CON rats (open cycle), HFD rats (open triangle) and DM rats (solid cycle). Data were expressed as mean±SD of 3–4 rats. bP<0.05, cP<0.01 vs CON rats. eP<0.05, fP<0.01 vs HFD rats.
