Table 3. Results of the final integrated model.
| Parameter | Original dataset |
Bootstrap replicatesa |
||||
|---|---|---|---|---|---|---|
| Estimate (%RSE) | 95% Confidence interval | Median | 95% Confidence interval | |||
| K | −0.0134 (12) | −0.0166 | −0.0102 | −0.0133 | −0.0167 | −0.00982 |
| R0 | 8.09 (5) | 7.34 | 8.84 | 8.07 | 5.77 | 10.13 |
| θ1 | 1.08 (17) | 0.72 | 1.44 | 1.08 | 0.55 | 1.59 |
| θ2 | 1.65 (15) | 1.18 | 2.12 | 1.66 | 0.890 | 2.42 |
| V0 (mL) | 6.97 (12) | 5.38 | 8.56 | 7.01 | 4.02 | 9.91 |
| θ3 (mL·Year−1) | 0.0484 (15) | 0.0339 | 0.0629 | 0.0488 | 0.0252 | 0.0727 |
| Emax (mL) | 4.42 (12) | 3.39 | 10.80 | 4.41 | 2.17 | 6.62 |
| EC50 | 0.707 (26) | 0.340 | 1.070 | 0.690 | 0.266 | 1.140 |
| θ4 | 0.432 (31) | 0.167 | 0.693 | 0.433 | 0.0395 | 0.904 |
| S0 | 11.6 (14) | 8.44 | 14.8 | 11.6 | 6.2 | 17.0 |
| θ5 | 4.56 (8.0) | 3.38 | 5.46 | 4.53 | 2.87 | 6.15 |
| K1 (mL−1) | 0.96 (23) | 0.53 | 1.39 | 0.96 | 0.47 | 1.45 |
| K2 (mL−1) | 1.36 (19) | 0.85 | 1.88 | 1.35 | 0.722 | 2.003 |
| BSV for K | 0.345 (21) | 0.0569 | 0.633 | 0.335 | 0.0358 | 0.680 |
| BSV for R0 | 0.341 (4) | 0.287 | 0.395 | 0.339 | 0.283 | 0.395 |
| BSV for V0 | 0.0347 (15) | 0.0149 | 0.0545 | 0.0348 | 0.0119 | 0.0615 |
| BSV for EC50 | 0.931 (10) | 0.561 | 1.300 | 0.934 | 0.512 | 1.394 |
| BSV for S0 | 0.0408 (12) | 0.0121 | 0.0541 | 0.0404 | 0.0211 | 0.0622 |
| AE for the R | 1.11 (13) | 0.557 | 1.660 | 1.09 | 0.570 | 1.613 |
| AE for V | 0.0391 (13) | 0.0196 | 0.0586 | 0.0388 | 0.0183 | 0.0633 |
| AE for S | 6.75 (9) | 4.36 | 9.14 | 6.67 | 4.28 | 9.10 |
| OFV | 3259.22 | – | – | 3232.00 | 3032.63 | 3428.23 |
BSV, between subject variability; AE, additional error; −, not included in the base model.
a Nonparametric bootstrap stratified by patient population (n=1000).