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. 2014 Aug 25;35(9):1199–1206. doi: 10.1038/aps.2014.60

Figure 3.

Figure 3

Analysis of pathways involved in mig-2-mediated cisplatin-induced apoptosis in H4 cells. Ectopic expression or knock-down of mig-2 in H4 cells treated with 40 μmol/L of cisplatin for 24 h. (A) Western blotting analysis of the total expression and activation of ERK1/2, JNK, p38, ERK5 and AKT. (B) Analysis of mig-2-mediated cisplatin-induced apoptosis when cells were pretreated with JNK inhibitor (SP600125, SP), p38 inhibitor (SB203580, SB) or AKT inhibitor (LY294002, LY) for 1 h. The data are presented as the mean±SD from three independent experiments. bP<0.05 versus control.