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. 2014 Sep 3;91(3):611–620. doi: 10.4269/ajtmh.13-0600

Figure 3.

Figure 3.

Comparative replication curves of lineages I and II DENV-2 strains ex vivo. (A and B) Mean virus output of lineage I (black columns) and lineage II (white columns) DENV-2 strains in mo-DCs from two healthy human donors at 48 hours post-infection; means ± SEs derived from four lineage I and seven lineage II DENV-2 strains are shown. (C) Combined mean virus output of lineage I (solid columns) and lineage II (open columns) DENV-2 strains in mo-DCs from both donors (data from two individual experiments pooled together) at 48 hours post-infection. The limit of detection of the assay is 0.9 log10 FFUs/mL (solid line). Although the statistical analysis of viral replication in these cells included days 0–2 post-infection, to allow clear visualization of both donors and all virus isolates, only titers on day 2 post-infection are shown.