Table 2.

Positively and negatively selected sites of the Loreto outbreak DENV-2 viruses

Gene	Length	dN/dS (95% confidence interval)	Number of positively selected sites		Number of negatively selected sites
			Strong positive (dN/dS) > 1 × 1010	Slightly positive (dN/dS) < 10
Total	3,391	0.066 (0.061–0.072)	67	35	1,920
C*	114	0.151 (0.102–0.214)	2	3	42 (37%)
prM	166	0.074 (0.051–0.101)	2	3	93 (56%)
Envelope	495	0.066 (0.053–0.082)	8	7	274 (55%)
NS1	352	0.074 (0.057–0.095)	5	2	201 (57%)
NS2a*	218	0.109 (0.086–0.135)	7	1	136 (62%)
NS2b	130	0.061 (0.039–0.090)	7	0	67 (52%)
NS3	618	0.040 (0.031–0.051)	10	4	366 (59%)
NS4a	149	0.074 (0.051–0.102)	2	4	90 (60%)
NS4b	249	0.044 (0.031–0.061)	6	0	143 (57%)
NS5	900	0.068 (0.058–0.080)	18	11	508 (56%)

^*Elevated d_N/d_S values.