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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Chem Rev. 2013 Jun 17;113(8):5701–5765. doi: 10.1021/cr4000144

Scheme 180.

Scheme 180

Synthesis of Indole Alkaloids via Friedel-Crafts Acylation of Bridged Amides: a) Quebrachamine by Ziegler and Bosch; b) Dihydrocleavamine by Bosch and Lesma; c) Tabersonine by Ziegler; d) Cleavamine by Hanaoka (please use double-column format for Scheme 180)