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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Chem Rev. 2013 Jun 17;113(8):5701–5765. doi: 10.1021/cr4000144

Table 13.

Hydrogenolysis of C–NC(O) Bond in Medium-Bridged Twisted Lactams by Aubé

graphic file with name nihms495222t14.jpg
entry 208 m n ring
system		 ratio of
443:444		 combined
yield (%)
1 208b 1 0 [4.2.1] 100:0 74
2 208a 1 1 [4.3.1] 25:75 95
3 208f 1 2 [4.4.1] 50:50 54
4 208c 2 0 [5.2.1] 100:0 72
5 208d 2 1 [5.3.1] 100:0 79
6 208e 3 0 [6.2.1] 100:0 89