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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Chem Rev. 2013 Jun 17;113(8):5701–5765. doi: 10.1021/cr4000144

Table 17.

Addition of Organometallic Reagent to Medium-Bridged Tricyclic Lactams by Aubé

graphic file with name nihms495222t19.jpg
entry 177 RLi R 487/488 yield (%)
1 177d MeLi Me 487a 95
2 177d sec-BuLi sec-Bu 487b 80
3 177d tert-BuLi tert-Bu 488a 90
4 177e MeLi Me 487c 92
5 177e sec-BuLi sec-Bu 487d 88
6 177e tert-BuLi tert-Bu 488b 90