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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Chem Rev. 2013 Jun 17;113(8):5701–5765. doi: 10.1021/cr4000144

Table 6.

Synthesis of Tetracyclic Bridged Lactams from Thiolactone-Isatin Hybrids by Chibale

graphic file with name nihms495222t8.jpg
entry n 218 ratio of
220 221		 combined
yield (%)		 ring system
of 220
1 1 218a 0:100 36 [5.2.1]
2 2 218b 0:100 18 [6.2.1]
3 3 218c 78:22 45 [7.2.1]
4 4 218d 16:84 31 [8.2.1]
5 5 218e 29:71 21 [9.2.1]