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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Chem Rev. 2013 Jun 17;113(8):5701–5765. doi: 10.1021/cr4000144

Table 9.

Reactions of Quincorine-Derived Bridged α-Amino Ether 372 with Nucleophiles via Bridged Iminium Ion 373 by Hoffmann

graphic file with name nihms495222t11.jpg
entry RX R yield of
374 (%)
1 Me3SiCN -CN 83
2 Me3SiN3 -N3 81
3 Bu3SnC≡CH -C≡CH 39
4 Me2C=C(OMe)OSiMe3 -C(CO2Me)Me2 66