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. 2014 Aug 28;8(Suppl 2):S8. doi: 10.1186/1753-6561-8-S2-S8

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Copyright © 2014 Kultys et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Feature 1: Extreme conservation of sequences displaying asparagine in Gram-negatives in position 13. Highlighting all AKL domain sequences in Gram-negative bacteria displaying asparagine (N) in position 13 exposes extreme conservation of the selected sequences throughout the length of the visualised protein. The total number of highlighted sequences is 48, including 46 identical (minor variation occurs only in two sequences in positions 2, 3, 6, 12, 14, 15, 20, 21, 23, 26, 30, 33 and 35). The underlying causes for this unusual conservation remain to be investigated. Due to the scale of this extreme conservation (nearly 5.4% of the whole Gram-negative dataset), the findings can have significant implications for the interpretation and evaluation of data.