Table 1.

ILD diagnostic criteria6

□IMAGING CRITERIA□
□□□Findings that indicate, indicate the possibility of, or do not rule out the possibility of, ILD or interstitial pneumonia
	□bilateral or unilateral, non-segmental
	ground-glass opacities
	consolidation
	reticular opacities
	□bilateral extensive centrilobular shadow
	□bilateral segmental shadow (3 or more segments)
□□□Findings that indicate the absence of ILD or interstitial pneumonia (other pulmonary disease or no adverse events)
	□segmental shadow (locally limited)
	□bronchiolar lesions (locally limited)
	□improvement of the shadow by treatment with antibacterial agents
	□shadow only in a radiated area
	□enlarged cardiac shadow
	□positive pulmonary ventilation/perfusion (V/Q) scan for pulmonary embolism
	□progression of cancer (pleural effusion, carcinomatous lymphangiosis and enlargement of a primary focus in the lung)
□□□Unable to evaluate
	□lack of image information
	□poor quality image
□CLINICAL DIAGNOSIS CRITERIA□
□□□Findings that indicate, indicate the possibility of, or do not rule out the possibility of, ILD or interstitial pneumonia
	□elevated LDH, SP-A, SP-D and KL-6
	□effectively treated by steroids
	□negative culture for pathogens
	□diagnosis of acute lung injury or ILD in lung biopsy or in the examination of tissue collected at autopsy
□□□Findings that indicate the absence of ILD or interstitial pneumonia (other pulmonary disease or no adverse events)
	□effectively treated by antibacterial agents
	□detection of pathogens in the blood or expectorated sputum
	□signs of heart failure
	□findings of pulmonary embolism
	□no diagnosis of acute lung injury or ILD in lung biopsy or in the examination of tissue collected at autopsy
	□spontaneously alleviated while taking Iressa 250mg tablets
□□□Unable to evaluate
	□no clinical data to verify ILD or interstitial pneumonia