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Efficacy of oral ramoplanin treatment for decolonization of VRE stool colonization in mice. High-density VRE colonization was established in all mice by administering orogastric VRE on day −8 in conjunction with subcutaneous clindamycin from days −10 to 0. Oral ramoplanin in drinking water (100 [□] or 500 [◊] μg/ml) was given from days 0 to 8 (solid line). Control mice received regular drinking water (•). Error bars represent SE.
