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Characterization of SesA as a diguanylate cyclase. SesA was prepared from the cyanobacterial expression system. The reactions included the Pb (bottom panel) or Pg (top panel) forms of SesA, which were incubated for 10 min with GTP. GTP and the product c-di-GMP were separated by HPLC. The mass spectra that proved the second peak to be c-di-GTP are shown in supplemental Fig. S1.
