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. 2014 Jul 10;289(36):24832–24844. doi: 10.1074/jbc.M114.565929

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Mortalin interacts with hnRNP-K and leads to activation of its downstream effectors MMP-2, MMP-3, and MMP-9. A, MCF7/mot-F and mot-N cells showed an increase in MMP-2, MMP-3, MMP-9, and hnRNP-K. B, hnRNP-K overexpression did not affect the level of mortalin. C, coimmunoprecipitation assay showing the presence of hnRNP-K in mortalin immunocomplexes. D, immunostaining of hnRNP-K revealed its enhanced nuclear localization in mot-F and mot-N cells. E, immunohistochemical detection of mortalin in human normal and cancer ovarian tissues. An increased level of mortalin expression and its enrichment in nuclei are seen in cancer tissue.