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. 2014 Jul 17;289(36):24885–24897. doi: 10.1074/jbc.M114.554519

FIGURE 7.

FIGURE 7.

Concomitant knockdown of AGAP001476 and cactus could not reverse the refractoriness toward Plasmodium caused by knockdown of cactus. Each mosquito was injected with a total of 0.4 μg of dsluc, dsAGAP001476, or dsCactus. Knockdown of AGAP001476 promoted Plasmodium development as observed earlier, but it did not affect the near refractoriness induced by Cactus depletion. The result suggests that the AGAP001476-mediated anti-Plasmodium response is Cactus-dependent. *, p < 0.05; **, p < 0.01; ***, p < 0.0001 by Kruskal-Wallis test and Dunn's multiple comparisons test.