FIGURE 6.
Nuclear HDAC5 inhibits SOST bone enhancer activity by masking MEF2. UMR106 cells were transiently transfected with control expression vector (−), expression plasmids for wt or mutant HDAC5s, and luciferase reporter plasmids as indicated in the figure. After 48 h, cells were lysed and luciferase activities were determined. Shown are mean ± S.E. of relative luciferase activities from four independent experiments.