FIG. 1.

Survival study results. (A) Results for nu/+ mice from three studies. The infecting doses ranged from 3.6 × 10⁶ to 3.3 × 10⁷ CFU/mouse. The mice were treated with posaconazole (Posa) at 0.1, 1, 2.5, 5, 10, or 25 mg/kg p.o. for 7 days and were observed for survival through day 30 postinfection. Controls received 0.5% Noble agar p.o. The mice treated with ≥2.5 mg/kg/day survived significantly longer than the control mice. (B) Results for athymic mice from three studies. The infecting doses ranged from 9 × 10⁶ to 1.9 × 10⁷ CFU/mouse. Mice were treated with posaconazole at 0.625, 1.25, 2.5, or 5 mg/kg p.o. for 7 days and were observed for survival through day 30 postinfection. Controls received 0.5% Noble agar p.o. The mice treated with ≥2.5 mg/kg/day survived significantly longer than the control mice.