FIG. 2.

Tissue W. dermatitidis counts. (A) Brain W. dermatitidis counts. Mice from two studies were infected with 3.6 × 10⁶ to 1.9 × 10⁷ CFU/mouse and were treated from days 1 to 7. When possible the brains were harvested from mice that succumbed during treatment, and the brains were harvested from all survivors on day 8. Regimens included posaconazole (Posa) at 2 and 25 mg/kg. Controls received 0.5% Noble agar. Treatment with posaconazole at both doses was superior to the control treatment. (B) Spleen W. dermatitidis counts. Groups of seven nu/+ mice were infected with 1.9 × 10⁷ CFU/mouse and were treated from days 1 to 7. When possible the spleens were harvested from mice that succumbed during treatment, and the spleens were harvested from all survivors on day 8. Controls received 0.5% Noble agar. Treatment with posaconazole at 25 mg/kg was superior to the control treatment.