Table 1.
Genes examined by functional category, with cellular location of the protein encoded by the gene and its UniProt accession ID
| Gene symbol |
Protein name |
Location |
UniProt ID |
|---|---|---|---|
| Signaling – Cell surface | |||
| ADORA2A | Adenosine receptor A2a | Cell surface | P29274 |
| AQP4 | Aquaporin 4 | Cell surface | P55087 |
| CHRNA7 | Cholinergic receptor, nicotinic α7 | Cell surface | P36544 |
| DRD2 | Dopamine receptor D2 | Cell surface | P14416 |
| EPHA1 | EPH receptor A1 | Cell surface | P21709 |
| FGFR1 | FGF receptor 1 | Cell surface | P11362 |
| GFRA1 | GDNF family receptor α1 | Cell surface | P56159 |
| GRM5 | Metabotropic glutamate receptor 5 | Cell surface | P41594 |
| IGF2R | Insulin-like growth factor 2 receptor | Cell surface | P11717 |
| INSR | Insulin receptor | Cell surface | P06213 |
| OPN1LW | Opsin 1, long-wave-sensitive | Cell surface | P04000 |
| P2RY1 | Purinergic receptor P2Y, G-protein coupled, 1 | Cell surface | P47900 |
| SCUBE3 | Signal peptide, CUB and EGF-like domain-containing protein 3 | Cell surface | Q8IX30 |
| TNMD | Tenomodulin | Cell surface | Q9H2S6 |
| VIPR1 | VIP receptor 1 | Cell surface | P32241 |
| VIPR2 | VIP receptor 2 | Cell surface | P41587 |
| Signaling – Intracellular | |||
| BCO2 | Beta-carotene oxygenase 2 | Intracellular | Q9BYV7 |
| CABP5 | Calcium binding protein 5 | Intracellular | Q9NP86 |
| CAMP | Cathelicidin antimicrobial peptide | Intracellular | P49913 |
| CDC42 | Cell division cycle 42 | Intracellular | P60953 |
| CHAT | Choline O-acetyltransferase | Intracellular | P28329 |
| CYP26B1 | Cytochrome P450 26B1 | Intracellular | Q9NR63 |
| NOS1 | Nitric oxide synthase 1 | Intracellular | P29475 |
| RASGRF1 | Ras-specific guanine nucleotide-releasing factor 1 | Intracellular | Q13972 |
| RLBP1 | Retinaldehyde binding protein 1 | Intracellular | P12271 |
| RPE65 | Retinoid isomerohydrolase | Intracellular | Q16518 |
| S100A12 | Protein S100-A12 | Intracellular | P80511 |
| ZNF185 | Zinc finger protein 185 | Intracellular | O15231 |
| Signaling – Transcription regulators | |||
| EGR1 | Early growth response protein 1 | Intracellular | P18146 |
| HIF1A | Hypoxia-inducible factor 1α | Intracellular | Q16665 |
| PER2 | Period circadian clock 2 | Intracellular | O15055 |
| RXRB | Retinoid X receptor β | Intracellular | P28702 |
| VDR | Vitamin D receptor | Intracellular | P11473 |
| Signaling – Secreted | |||
| ANGPTL7 | Angiopoietin-related protein 7 | Extracellular | O43827 |
| APOE | Apolipoprotein E | Extracellular | P02649 |
| BMP2 | Bone morphogenetic protein 2 | Extracellular | P12643 |
| BMP4 | Bone morphogenetic protein 4 | Extracellular | P12644 |
| CILP | Cartilage intermediate layer protein 1 | Extracellular | O75339 |
| EGF | Epidermal growth factor | Extracellular | P01133 |
| FAM180A | Family with sequence similarity 180, member A | Extracellular | Q6UWF9 |
| IGF2 | Insulin-like growth factor 2 | Extracellular | P01344 |
| IL1B | Interleukin 1β | Extracellular | P01584 |
| LTBP1 | Latent TGFβ binding protein 1 | Extracellular | Q14766 |
| LTF | Lactotransferrin | Extracellular | P02788 |
| MEST | Mesoderm specific transcript | Extracellular | Q5EB52 |
| NRG1 | Neuregulin 1 | Extracellular | Q02297 |
| NTS | Neurotensin | Extracellular | P30990 |
| PENK | Proenkephalin A | Extracellular | P01210 |
| PI15 | Peptidase inhibitor 15 | Extracellular | O43692 |
| PTX3 | Pentraxin 3 | Extracellular | P26022 |
| SOSTDC1 | Sclerostin domain-containing protein 1 | Extracellular | Q6X4U4 |
| SST | Somatostatin | Extracellular | P61278 |
| TAC1 | Protachykinin 1 | Extracellular | P20366 |
| TGFB2 | Transforming growth factor β2 | Extracellular | P61812 |
| TGFB3 | Transforming growth factor β3 | Extracellular | P10600 |
| TGFBI | TGFβ-induced protein | Extracellular | Q15582 |
| VIP | Vasoactive intestinal peptide | Extracellular | P01282 |
| Signaling – Matricellular | |||
| CYR61 | Protein CYR61 | Extracellular | O00622 |
| NOV | Nephroblastoma overexpressed gene | Extracellular | P48745 |
| THBS1 | Thrombospondin 1 | Extracellular | P07996 |
| THBS2 | Thrombospondin 2 | Extracellular | P35442 |
| TNC | Tenascin C | Extracellular | P24821 |
|
| |||
| MPs/TIMPs | |||
| ADAMTS4 | ADAM metallopeptidase with thrombospondin motif, 4 | Extracellular | O75173 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin motif, 5 | Extracellular | Q9UNA0 |
| ADAMTSL3 | ADAMTS-like 3 | Extracellular | P82987 |
| MMP14 | Matrix metallopeptidase 14 | Cell surface | P50281 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | Extracellular | P16035 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | Extracellular | P35625 |
|
| |||
| Extracellular matrix | |||
| COL12A1 | Collagen type XII, α1 | Extracellular | Q99715 |
| COL6A6 | Collagen type VI, α6 | Extracellular | A6NMZ7 |
| DCN | Decorin | Extracellular | P07585 |
| FMOD | Fibromodulin | Extracellular | Q06828 |
| MXRA5 | Matrix remodeling associated protein 5 | Extracellular | Q9NR99 |
| NYX | Nyctalopin | Extracellular | Q9GZU5 |
| OGN | Mimecan | Extracellular | P20774 |
| PRELP | Prolargin | Extracellular | P51888 |
| SERPINH1 | Serpin H1 | Intracellular | P50454 |