Table 3.
Genes that were significantly regulated in treated vs. control eyes under GO, STAY, or STOP conditions.
| Functional category | GO (LIM-2) | STAY (LIM-11) | STOP (REC-2) | |
|---|---|---|---|---|
| Signaling - Cell surface | B | EPHA1 | EPHA1 x | EPHA1 |
| B | SCUBE3 | SCUBE3 x | SCUBE3 | |
| P2RY1 | P2RY1 | |||
| FGFR1 | ||||
| Signaling - Intracellular | B | BCO2 | BCO2 | |
| B | ZNF185 | ZNF185 | ||
| CYP26B1 | CYP26B1 | |||
| RLBP1 x | RLBP1 | RLBP1 | ||
| RPE65 | RPE65 x | |||
| CHAT | ||||
| Signaling - Transcription | HIF1A | |||
| Signaling - Secreted | B | IGF2 | IGF2 | IGF2 |
| B | NRG1 | NRG1 | NRG1 | |
| B | PI15 | PI15 | PI15 | |
| B | FAM180A | FAM180A | ||
| B | MEST | MEST | MEST | |
| B | SOSTDC1 | SOSTDC1 | ||
| BMP2 | BMP2 x | BMP2 x | ||
| BMP4 | BMP4 | |||
| TGFBI | TGFBI | |||
| CILP | CILP | |||
| PENK | PENK | |||
| PTX3 | PTX3 | |||
| ANGPTL7 | ||||
| EGF x | ||||
| TGFB2 | ||||
| TGFB3 | ||||
| Signaling - Matricellular | B | NOV | NOV | |
| THBS1 | THBS1 | |||
| CYR61 | ||||
| TNC | ||||
| MPs/TIMPs | B | ADAMTSL3 | ADAMTSL3 | ADAMTSL3 |
| TIMP3 | ||||
| ADAMTS5 | ||||
| Extracellular matrix | B | COL6A6 | COL6A6 | |
| COL12A1 | ||||
| OGN | ||||
| MXRA5 | ||||
| NYX | ||||
“B” = bi-directional regulation between GO and STOP, red gene symbols = down-regulation, blue = up-regulation, “X” = differential expression likely due to control eye effect.