Table 1.
Clinical studies showing a direct association between CRP and leptin plasma levels.
| Subjects (N and description) | AgeMean±SD or range | CRP (mg/L)Mean±SD or median | Leptin (ng/ml)Mean±SD or median | Statistical Correlations |
|---|---|---|---|---|
| 179 healthy volunteersa | 18-22 | 0.51±1.45 | 2.3±2.9 | R =0.28, P<0.0002 |
| 100 healthy volunteersb | 36±2 | 3.07±0.046 W1.06±0.012 M | 16.9±2 W5.5±0.5 M | R=0.61, P<0.0001 WR=0.55, P<0.0001 M |
| 946 healthy community-dwelling, older adultsc | 65-102 | 2.8 (4.4) | 8.6 (12.3) | β = 0.20, P <0.0001 |
| 1862 healthy young adultsd | 24-39 | 0.75 (0.32-1.93) W0.56 (0.29-1.27) M | 12.5(7.8-19.5) W4.1(2.4-6.5) M | R=0.47, P<0.0001 WR=0.46, P<0.0001 M |
| 20 OB5 NO e | 47.8±13.3 OB56.8±7.6 NO | 5.7±3.4 OB3.8±1.6 NO | 17.6±8.7 OB6.2±3.3 NO | R=0.43,P<0.044 # |
| 63 (28 MO)f | 35±6.89 | 8.2 (0.13-56.6) | 52.7±19.8 MO7.6±4.8 | R=0.53,P<0.001# |
| 148 with T2Dg | 37-84 | 0.788±0.049 | 5.6±0.4 | R=0.330, P<0.001 |
| 150 with T2Dh | 52.8±11.1 W51.9±9.9 M | 2.34±1.651.72±2.1 | 9.82±6.784.76±2.44 | β= 0.326, P = 0.01 |
| 6251 (598 withT2D)i | 44.4±0.21 § | NA | NA | ρ = 0.32, P<0.0001 Wρ = 0.22, P<0.0001 M |
| 1460 (894 with T2D)l | 30-77 | 1.7(0.8-3.8) | 12.1(6.5-23.2) | R=0.41, P<0.001 WR=0.29, P<0.001 M |
[27]a ; [28]b; [29]c; [30]d; [31]e; [32]f; [33]g; [34]h; [35]i; [38]l
W=women; M=men; OB=obese; NO=non-obese; MO=morbidly obese; T2D= type 2 diabetes; NA=not available
#
The correlations were not longer significant after adjustment for BMI in obese individuals; § values are expressed as mean ±SE