TABLE 3.
Treatment (dose) | Mean log10 no. of CFU/organ (no. of animals free of infection) [95% confidence interval]/P valueb
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---|---|---|---|---|---|---|
Strain 98-1037
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Strain 98-293
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Spleen | Liver | Lungs | Spleen | Liver | Lungs | |
None (control) lipid complex | 6.14 (0) [5.2-6.7] | 6.81 (0) [5.5-6.9] | 6.11 (0) [4.9-6.8] | 6.27 (0) [5.9-6.9] | 6.45 (0) [5.3-6.8] | 6.91 (0) [5.2-7.2] |
AMB (1 mg/kg) | 1.47 (3) [0-2.3]/0.003 | 3.41 (0) [2.2-4.5]/0.0006 | 3.78 (1) [0.04-4.2] | 1.52 (2) [0-2.2]/0.0002 | 3.33 (0) [2.6-4.1]/0.0002 | 3.98 (0) [2.7-4.3]/0.0002 |
AMB colloidal dispersion (1 mg/kg) | 1.21 (5) [0-1.8]/0.0006 | 2.62 (2) [0-4.1]/0.4418 | 3.15 (4) [0-4.7] | 1.04 (4) [0-1.6]/0.0002 | 2.87 (2) [0.7-3.3]/0.0002 | 3.01 (4) [0-3.6]/0.0002 |
Liposomal AMB (1 mg/kg) | 1.39 (4) [0-2.1]/0.0006 | 3.11 (0) [2.5-4.2]/0.0006 | 3.29 (3) [0.6-3.9] | 1.16 (3) [0-2.6]/0.0002 | 3.07 (0) [2.8-3.9]/0.0002 | 3.31 (3) [0-4.1]/0.0002 |
AMB | ||||||
0.5 mg/kg intravenous | 0.35 (5) [0-0.7] | 1.39 (2) [0-3.2] | 1.08 (2) [0-2.1] | 0.31 (4) [0-0.9] | 1.17 (2) [0-3.1] | 1.48 (2) [0-2.6] |
1 mg/kg intraperitoneal | 0.41 (5) [0-0.9] | 2.45 (1) [0-3.6] | 2.48 (2) [0-2.9] | 0.39 (5) [0-2.2] | 1.98 (2) [0-2.7] | 1.86 (2) [0-2.5] |
There were 10 animals per group. Survivors were sacrificed on day 24.
Compared with AMP-treated group (1 mg/kg).