TABLE 3.

Fungal burden in spleens, livers, and lungs of mice infected with 200 arthroconidia of Coccidioides sp. strains 98-1037 and 98-293^a

Treatment (dose)	Mean log10 no. of CFU/organ (no. of animals free of infection) [95% confidence interval]/P valueb
	Strain 98-1037			Strain 98-293
	Spleen	Liver	Lungs	Spleen	Liver	Lungs
None (control) lipid complex	6.14 (0) [5.2-6.7]	6.81 (0) [5.5-6.9]	6.11 (0) [4.9-6.8]	6.27 (0) [5.9-6.9]	6.45 (0) [5.3-6.8]	6.91 (0) [5.2-7.2]
AMB (1 mg/kg)	1.47 (3) [0-2.3]/0.003	3.41 (0) [2.2-4.5]/0.0006	3.78 (1) [0.04-4.2]	1.52 (2) [0-2.2]/0.0002	3.33 (0) [2.6-4.1]/0.0002	3.98 (0) [2.7-4.3]/0.0002
AMB colloidal dispersion (1 mg/kg)	1.21 (5) [0-1.8]/0.0006	2.62 (2) [0-4.1]/0.4418	3.15 (4) [0-4.7]	1.04 (4) [0-1.6]/0.0002	2.87 (2) [0.7-3.3]/0.0002	3.01 (4) [0-3.6]/0.0002
Liposomal AMB (1 mg/kg)	1.39 (4) [0-2.1]/0.0006	3.11 (0) [2.5-4.2]/0.0006	3.29 (3) [0.6-3.9]	1.16 (3) [0-2.6]/0.0002	3.07 (0) [2.8-3.9]/0.0002	3.31 (3) [0-4.1]/0.0002
AMB
0.5 mg/kg intravenous	0.35 (5) [0-0.7]	1.39 (2) [0-3.2]	1.08 (2) [0-2.1]	0.31 (4) [0-0.9]	1.17 (2) [0-3.1]	1.48 (2) [0-2.6]
1 mg/kg intraperitoneal	0.41 (5) [0-0.9]	2.45 (1) [0-3.6]	2.48 (2) [0-2.9]	0.39 (5) [0-2.2]	1.98 (2) [0-2.7]	1.86 (2) [0-2.5]

^aThere were 10 animals per group. Survivors were sacrificed on day 24.

^bCompared with AMP-treated group (1 mg/kg).