TABLE I. Concentrations of antimony (μg/g) in rat tissues 24-h and 21-days after a 21-days treatment with meglumine antimoniate (MA)a .
| Tissue | Time after the last
injection of MA |
|
|---|---|---|
| 1 day | 21 days | |
| Spleen | 148.0 ± 14.0 | 81.9 ± 4.6b |
| Kidneys | 31.1 ± 1.9 | 5.4 ± 0.4b |
| Femur | 28.2 ± 0.7 | 18.3 ± 0.8b |
| Thyroid gland | 25.2 ± 4.5 | 18.0 ± 1.2 |
| Liver | 13.8 ± 1.3 | 3.2 ± 0.2b |
| Epididymis | 10.9 ± 0.7 | 1.2 ± 0.1b |
| Lungs | 10.2 ± 0.8 | 7.7 ± 0.7b |
| Adrenals | 7.4 ± 0.5 | 5.9 ± 0.5 |
| Prostate | 3.2 ± 0.5 | 1.0 ± 0.2b |
| Thymus | 3.1 ± 0.2 | 1.6 ± 0.2b |
| Small intestines | 2.7 ± 0.3 | 1.8 ± 0.3b |
| Skeletal muscle | 2.2 ± 0.4 | 0.6 ± 0.1b |
| Testes | 2.0 ± 0.1 | 1.0 ± 0.2b |
| Stomach | 1.7 ± 0.2 | 1.0 ± 0.1b |
| Pancreas | 3.0 ± 0.4 | 2.5 ± 0.4 |
| Heart | 2.8 ± 0.3 | 2.7 ± 0.3 |
| Brain | 0.6 ± 0.0 | 0.5 ± 0.0 |
a: 300 mg mg SbV/kg body wt/d subcutaneous; b: differ from Sb concentrations measured 24-h after treatment (Student t test, p < 0.05). Values are means ± standard deviation, n = 6 rats/group.