Fig. 3.

Effect of enclomiphene citrate on the pharmacodynamics of serum LH compared with transdermal testosterone. The effects of various treatments are seen over 24 h and compared between an initial dose and a dose given after 6 weeks of continuous treatment. Men with AIHH were treated with (A) transdermal testosterone according to label instructions initially (open triangles and dashed line) and after daily dosing (filled triangles and solid line); (B) enclomiphene citrate 6.25 mg initially (open diamonds and dashed line) and after daily oral dosing (filled diamond and solid line); (C) enclomiphene citrate 12.5 mg initially (open circles and dashed line) and after daily oral dosing (filled circles and solid line); and (D) enclomiphene citrate 25 mg initially (open squares and dashed line) and after daily oral dosing (filled squares and solid line.) A second order polynomial is fitted to the data points and the R² value is given next to the line.