FIG. 2.

Activities of 9 and 90 μM PF-18 against nonencapsulated GBS (Ia HD; A) and encapsulated GBS (Ia LD; B) in the presence or absence of 10 mg of a modified porcine surfactant preparation (Curosurf) per ml. Mean + SD values from three measurements are shown. Values for 9 μM PF-18 are not significantly different from those for the GBS Ia LD and HD phase variant controls. With 90 μM PF-18, a significant growth reduction was observed after 4 h, both in the presence and in the absence of surfactant (P < 0.05 versus the results for the GBS Ia LD and HD phase variants). Like for LL-37 (Fig. 1), some of the bactericidal effects of the PF-18 were blocked in the presence of surfactant.