TABLE 3.
MICs of tigecycline and tetracyclines for isogenic E. coli strains harboring plasmids carrying efflux-pump related genes
| Compound | MIC (μg/ml)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| TG1 (acrAB+) | KAM3 (acrB) | KAM3 harboringa:
|
||||||
| pLGT2 Tet(B) | pBR322 Tet(C) | pTZ1252 Tet(K) | pUCacrAB | pTrcHacrEF | pTrcHbcr | |||
| Tigecycline | 0.5 | 0.125 | 0.125 | 0.125 | 0.125 | 0.5 | 0.5 | 0.125 |
| DMG-DMDOT | 1 | 0.5 | 0.5 | 2 | 0.25 | 0.5 | 1 | 0.5 |
| Minocycline | 2 | 0.25 | 2 | 0.5 | 0.25 | 1 | 2 | 0.25 |
| Doxycycline | 2 | 0.25 | 8 | 2 | 1 | 1 | 2 | 0.25 |
| Tetracycline | 2 | 0.5 | 128 | 32 | 16 | 1 | 1 | 2 |
a
Values in boldface differ significantly (more than fourfold) from the value for the KAM3 control strain.