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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Anal Chem. 2008 Mar 20;80(8):2728–2733. doi: 10.1021/ac702213d

Table 3.

A comparison of free-solution, label-free molecular interaction assays (Based upon Ref. 34)

Technique Minimum Sample Volume Detection Limits
Microcal ITC 1.3 mL 1.0 × 10-6 M 1.3 nmol
Enthalpy arrays 500 nL 5.0 × 10-5 M 25 pmol
BSI 350 pL 8.6 × 10-11 M 30 zmol
nCal 50 nL 2.9 × 10-12 150 zmol