Table 2.

Relationship between serum Aβ level and cognitive function (MMSE score)

	Total subjects					60–69 years old					70 years and older
	B	SE	β	t-value	P-value	B	SE	β	t-value	P-value	B	SE	β	t-value	P-value
Aβ40
Age	−0.064	0.020	−0.163	−3.268	<0.01	−0.038	0.046	−0.050	−0.830	0.407	−0.069	0.054	−0.100	−1.298	0.196
Sex	0.770	0.272	0.146	2.833	<0.01	0.722	0.305	0.169	2.368	<0.05	0.892	0.507	0.143	1.761	0.080
Education	0.377	0.063	0.292	5.962	<0.001	0.347	0.073	0.293	4.744	<0.001	0.416	0.113	0.285	3.661	<0.001
Pack-years of smoking	−0.009	0.008	−0.056	−1.143	0.254	−0.017	0.009	−0.130	−1.920	0.056	0.002	0.014	0.011	0.148	0.883
TMIG-IC score	0.455	0.095	0.214	4.805	<0.001	0.269	0.106	0.155	2.533	<0.05	0.699	0.175	0.281	3.986	<0.001
Positive history of
Diabetes mellitus	−0.020	0.374	−0.002	−0.053	0.958	−0.413	0.467	−0.056	−0.883	0.378	0.321	0.612	0.037	0.524	0.601
Hypertension	0.189	0.231	0.037	0.816	0.415	0.227	0.259	0.053	0.879	0.380	0.146	0.429	0.024	0.340	0.734
Dyslipidemia	0.371	0.283	0.060	1.311	0.191	0.120	0.313	0.024	0.382	0.703	0.746	0.538	0.097	1.388	0.167
Aβ40	−0.004	0.012	−0.015	−0.320	0.749	−0.010	0.014	−0.041	−0.671	0.503	0.006	0.021	0.020	0.277	0.782
Aβ42
Age	−0.066	0.019	−0.166	−3.411	<0.01	−0.044	0.046	−0.058	−0.962	0.337	−0.068	0.054	−0.097	−1.269	0.206
Sex	0.768	0.271	0.146	2.837	<0.01	0.713	0.304	0.167	2.349	<0.05	0.903	0.509	0.145	1.776	0.078
Education	0.378	0.063	0.292	5.986	<0.001	0.347	0.073	0.292	4.748	<0.001	0.413	0.113	0.284	3.648	<0.001
Pack-years of smoking	−0.009	0.008	−0.056	−1.140	0.255	−0.016	0.009	−0.128	−1.897	0.059	0.002	0.014	0.012	0.149	0.882
TMIG-IC score	0.453	0.094	0.213	4.798	<0.001	0.261	0.106	0.150	2.470	<0.05	0.699	0.176	0.281	3.983	<0.001
Positive history of
Diabetes mellitus	−0.036	0.369	−0.004	−0.098	0.922	−0.448	0.464	−0.061	−0.966	0.335	0.355	0.606	0.041	0.585	0.559
Hypertension	0.179	0.230	0.035	0.779	0.437	0.219	0.258	0.051	0.846	0.398	0.171	0.424	0.028	0.403	0.687
Dyslipidemia	0.372	0.282	0.060	1.318	0.188	0.127	0.312	0.026	0.406	0.685	0.737	0.537	0.096	1.372	0.172
Aβ42	−0.007	0.043	−0.008	−0.175	0.861	−0.005	0.038	−0.008	−0.138	0.891	−0.002	0.219	−0.001	−0.010	0.992
Aβ40/Aβ42
Age	−0.066	0.019	−0.167	−3.416	<0.01	−0.045	0.046	−0.059	−0.983	0.327	−0.068	0.053	−0.097	−1.276	0.204
Sex	0.763	0.271	0.145	2.817	<0.01	0.707	0.304	0.165	2.327	<0.05	0.902	0.505	0.145	1.785	0.076
Education	0.376	0.063	0.291	5.950	<0.001	0.341	0.073	0.287	4.642	<0.001	0.413	0.113	0.284	3.643	<0.001
Pack-years of smoking	−0.009	0.008	−0.055	−1.114	0.266	−0.016	0.009	−0.121	−1.778	0.077	0.002	0.014	0.012	0.153	0.878
TMIG-IC score	0.452	0.094	0.213	4.787	<0.001	0.260	0.106	0.150	2.465	<0.05	0.701	0.176	0.282	3.988	<0.001
Positive history of
Diabetes mellitus	−0.050	0.371	−0.006	−0.135	0.892	−0.502	0.469	−0.068	−1.068	0.286	0.356	0.601	0.041	0.592	0.554
Hypertension	0.179	0.230	0.035	0.776	0.438	0.218	0.258	0.051	0.843	0.400	0.173	0.421	0.029	0.412	0.681
Dyslipidemia	0.376	0.282	0.060	1.332	0.184	0.128	0.312	0.026	0.411	0.682	0.733	0.537	0.096	1.364	0.174
Aβ40/Aβ42	0.010	0.030	0.015	0.334	0.739	0.026	0.035	0.045	0.737	0.462	−0.008	0.054	−0.010	−0.148	0.883

Abbreviations: Aβ, amyloid beta; MMSE, Mini-Mental State Examination; SE, standard error; TMIG-IC, Tokyo Metropolitan Institute of Gerontology Index of Competence.