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Stimulation of PKA enhances VAMP2-NKCC2 interaction in TALs. Incubation of TAL suspensions with a 1 mm concentration of the PKA-selective agonist N6Bnz-cAMP for 30 min enhanced NKCC2-VAMP2 interaction by 108 ± 12%, as measured by co-immunoprecipitation. Treatment with N6Bnz-cAMP did not affect NKCC2 protein levels (top). Values are expressed as mean percentage of vehicle, and error bars represent S.E. *, p < 0.01 versus vehicle (n = 5).
