FIGURE 8.

Special conformation adopted by the intact core when bound to the lipid A. Shown is part of the ROESY spectrum of 3 with NOE signals showing interresidual connectivities between H-3_ax of Kdo and H-3/H-5 of Man^I. This indicates a free rotation in the core oligosaccharide of about 180° (gray arrow) around the Man^I-C1-O-C5-Kdo bond axis as shown in the bottom part together with the membrane matrix of the DHPC micelles. Indicated are the two disaccharides attached to Man^I (i.e. α-l-Rhap-(1→3)-β-d-Galp-(1→ (OR¹) and α-d-GalNp-(1→6)-α-d-Manp^II-(1→4) (OR²)).