FIG. 1.

Effects of MXF on the production of IL-8, TNF-α, and IL-1β by LPS-stimulated monocytes and THP-1 cells. Monocytes and THP-1 cells were preincubated in the presence or absence of MXF (5 to 20 μg/ml). LPS was added to the cells at 10 and 100 ng/ml, respectively, and the cells were further incubated for 4 and 24 h, respectively. The concentrations of IL-8, TNF-α, and IL-1β in the culture supernatants were measured by ELISA; and the values are the means + standard errors of three independent experiments. Asterisks denote a statistically significant difference compared with the results for the LPS-stimulated cells without MXF. (P < 0.05).