Skip to main content
. 2014 Jul 8;289(34):23504–23519. doi: 10.1074/jbc.M114.553305

FIGURE 6.

FIGURE 6.

Amino acid sequence alignment of PYDs to determine conservation of residues that mediate interaction of pyrin and ASC PYDs. Sequence alignment of ASC PYD (NP_037390), pyrin PYD (AF018080), and the PYDs of other human proteins that interact with ASC including POP1 (NP_690865), NLRP1 (NP_127497.1), NLRP3 (AF468522.1), NLRP4 (NP_604393), NLRP6 (NP_612202), NLRP7 (AAI09126), NLRP12 (NP_653288), and AIM2 (AAH10940). Acidic and basic residues important for interaction of ASC PYD and pyrin PYD are indicated in red and blue, respectively. Sequence positions that contribute to binding sites 1, 2, and 3 are shaded in pink, blue, and gray, respectively. Residues corresponding to these binding sites that are conserved in other PYDs are shown in bold.