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Schematic of proposed Bcl-2 family BH3 protein interactions in differentiation. LPS- and cytokine-driven differentiation induces Bim while decreasing expression of Mcl-1 and Bcl-2. Bcl-xL is induced and binds Bim that is displaced. ABT-737 blocks Bcl-xL, releasing Bim, which is then free to activate Bax and Bak, resulting in the induction of apoptosis.
