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. 2004 Jun;48(6):2149–2152. doi: 10.1128/AAC.48.6.2149-2152.2004

TABLE 1.

In vitro activities of telavancin (TD-6424) against 271 recent clinical isolates of gram-positive anaerobes and corynebacteria

Antimicrobial MIC (μg/ml)a
Antimicrobial MIC (μg/ml)a
Range 50% 90% Range 50% 90%
Actinomyces israelii (n = 13)
    Telavancin 0.125-0.25 0.25 0.25
    Daptomycin 0.5->32 2 4
    Vancomycin 0.5-1 0.5 1
    Linezolid 0.25-16 0.5 16
    Quinupristin-dalfopristin 0.125-0.5 0.25 0.25
    Imipenem ≤0.03-0.25 ≤0.03 0.125
    Piperacillin-tazobactam ≤0.03-4 ≤0.03 4
    Ampicillin ≤0.03-0.5 ≤0.03 0.5
Actinomyces meyeri-A. turicensis groupb (n = 12)
    Telavancin 0.125-0.25 0.125 0.25
    Daptomycin 0.5-16 2 8
    Vancomycin 0.25-1 0.5 0.5
    Linezolid 0.125-1 0.5 0.5
    Quinupristin-dalfopristin 0.06-0.5 0.125 0.125
    Imipenem ≤0.03-0.125 0.125 0.125
    Piperacillin-tazobactam ≤0.03-2 0.5 1
    Ampicillin 0.125-0.5 0.25 0.5
Actinomyces odontolyticus (n = 10)
    Telavancin 0.125-0.25 0.25 0.25
    Daptomycin 16->32 16 32
    Vancomycin 0.5-1 1 1
    Linezolid 0.5-1 0.5 0.5
    Quinupristin-dalfopristin 0.125-0.5 0.25 0.25
    Imipenem 0.06-0.25 0.125 0.125
    Piperacillin-tazobactam 0.25-4 1 4
    Ampicillin 0.06-0.5 0.125 0.5
Actinomyces viscosus (n = 10)
    Telavancin 0.125-0.25 0.125 0.25
    Daptomycin 0.5-8 4 8
    Vancomycin 0.5-0.5 0.5 0.5
    Linezolid 0.5-0.5 0.5 0.5
    Quinupristin-dalfopristin 0.06-0.5 0.25 0.25
    Imipenem ≤0.03-≤0.03 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.5 0.125 0.5
    Ampicillin ≤0.03-0.06 0.06 0.06
Clostridium clostridioforme (n = 15)
    Telavancin 0.25-8 1 8
    Daptomycin 0.25-8 1 4
    Vancomycin 0.25->32 0.5 1
    Linezolid 2-4 2 4
    Quinupristin-dalfopristin 0.125-8 0.5 4
    Imipenem 0.5-2 1 2
    Piperacillin-tazobactam 0.25-64 4 8
    Ampicillin 0.5->32 1 1
Clostridium difficile (n = 14)
    Telavancin 0.125-0.5 0.25 0.25
    Daptomycin 0.5-2 0.5 2
    Vancomycin 0.25-2 0.5 1
    Linezolid 2-8 2 8
    Quinupristin-dalfopristin 0.25-2 0.25 1
    Imipenem 2-32 4 8
    Piperacillin-tazobactam 4-16 8 16
    Ampicillin 0.5-2 1 2
Clostridium innocuum (n = 15)
    Telavancin 2-4 4 4
    Daptomycin 2-8 4 8
    Vancomycin 8-16 16 16
    Linezolid 2-4 2 2
    Quinupristin-dalfopristin 0.125-1 0.25 0.25
    Imipenem 1-2 2 2
    Piperacillin-tazobactam 0.5-4 1 2
    Ampicillin 0.125-0.25 0.125 0.25
Clostridium perfringens (n = 12)
    Telavancin 0.06-0.125 0.06 0.125
    Daptomycin 0.25-1 1 1
    Vancomycin 0.5-0.5 0.5 0.5
    Linezolid 2-2 2 2
    Quinupristin-dalfopristin 0.125-0.5 0.25 0.5
    Imipenem ≤0.03-0.25 0.06 0.125
    Piperacillin-tazobactam ≤.03-2 0.06 0.5
    Ampicillin ≤0.03-0.06 ≤0.03 0.06
Clostridium ramosum (n = 16)
    Telavancin 0.25-8 0.5 1
    Daptomycin 8->32 32 32
    Vancomycin 1-8 4 4
    Linezolid 4-8 8 8
    Quinupristin-dalfopristin 0.125-2 0.25 2
    Imipenem 0.125-2 0.25 0.5
    Piperacillin-tazobactam ≤0.03-1 0.06 0.5
    Ampicillin ≤0.03-1 0.06 0.25
Eubacterium lentum (n = 10)
    Telavancin 0.125-0.25 0.25 0.25
    Daptomycin 1-32 16 32
    Vancomycin 0.5-1 1 1
    Linezolid 0.5-2 2 2
    Quinupristin-dalfopristin 0.125-0.5 0.25 0.5
    Imipenem ≤0.03-0.25 0.25 0.25
    Piperacillin-tazobactam ≤0.03-32 16 16
    Ampicillin ≤0.03-0.5 0.25 0.5
Eubacterium limosum (n = 10)
    Telavancin 0.06-0.25 0.125 0.25
    Daptomycin 0.06-0.5 0.25 0.25
    Vancomycin 0.25-2 2 2
    Linezolid 1-4 2 4
    Quinupristin-dalfopristin 0.125-2 0.25 1
    Imipenem ≤0.03-≤0.03 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-2 ≤0.03 0.25
    Ampicillin ≤0.03-0.125 ≤0.03 0.06
Eubacterium groupc (n = 13)
    Telavancin 0.03-1 0.25 0.25
    Daptomycin 0.06-8 0.5 0.5
    Vancomycin 0.25-4 1 2
    Linezolid 0.5-2 2 2
    Quinupristin-dalfopristin ≤0.03-1 0.5 1
    Imipenem ≤0.03-0.125 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.5 ≤0.03 0.5
    Ampicillin ≤0.03-0.125 ≤0.03 0.06
Lactobacillus plantarum (n = 10)
    Telavancin 0.125-0.25 0.25 0.25
    Daptomycin 8->32 32 >32
    Vancomycin 0.5-4 4 4
    Linezolid 4-8 8 8
    Quinupristin-dalfopristin 0.5-2 0.5 2
    Imipenem 0.125-0.5 0.125 0.25
    Piperacillin-tazobactam ≤0.03-1 0.06 0.5
    Ampicillin ≤0.03-0.5 ≤0.03 0.25
Lactobacillus casei (n = 6)
    Telavancin 32->64 32
    Daptomycin 1-4 2
    Vancomycin >32->32 >32
    Linezolid 4 4
    Quinupristin-dalfopristin 0.5-1 1
    Imipenem 1-16 2
    Piperacillin-tazobactam 1-8 4
    Ampicillin 0.5-4 1
Lactobacillus sp.d (n = 16)
    Telavancin ≤0.015-2 0.25 1.25
    Daptomycin 0.25->32 4 >32
    Vancomycin 0.25-8 1 4
    Linezolid 1-8 4 8
    Quinupristin-dalfopristin 0.125-4 0.25 1
    Imipenem ≤0.03-1 0.06 0.25
    Piperacillin-tazobactam ≤0.03-1 0.25 1
    Ampicillin ≤0.03-1 0.125 0.5
Propionibacterium acnes (n = 12)
    Telavancin 0.06-0.125 0.125 0.125
    Daptomycin 0.125-1 0.5 1
    Vancomycin 0.25-0.5 0.5 0.5
    Linezolid 0.25-0.5 0.5 0.5
    Quinupristin-dalfopristin ≤0.03-0.5 0.125 0.125
    Imipenem ≤0.03-≤.03 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.5 0.125 0.5
    Ampicillin ≤0.03-0.125 0.06 0.06
Propionibacterium avidum (n = 12)
    Telavancin 0.125-0.25 0.125 0.125
    Daptomycin 1-2 2 2
    Vancomycin 0.5-0.5 0.5 0.5
    Linezolid 0.5-1 0.5 0.5
    Quinupristin-dalfopristin 0.125-0.125 0.125 0.125
    Imipenem ≤0.03-≤0.03 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-1 0.5 1
    Ampicillin ≤0.03-0.125 0.125 0.125
Propionibacterium granulosum (n = 10)
    Telavancin 0.06-0.125 0.06 0.125
    Daptomycin 0.125-1 0.5 1
    Vancomycin 0.5-1 0.5 1
    Linezolid 0.25-0.5 0.25 0.25
    Quinupristin-dalfopristin 0.06-0.125 0.125 0.125
    Imipenem ≤0.03-0.06 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-1 ≤0.03 ≤0.03
    Ampicillin ≤0.03-0.5 0.06 0.06
Peptostreptococcus anaerobius (n = 10)
    Telavancin 0.06-0.25 0.06 0.25
    Daptomycin 0.25-4 0.25 0.5
    Vancomycin 0.25-0.5 0.25 0.5
    Linezolid 0.5-8 0.5 8
    Quinupristin-dalfopristin 0.06-0.5 0.125 0.25
    Imipenem ≤0.03-0.06 ≤0.03 0.06
    Piperacillin-tazobactam ≤0.03-1 0.25 0.25
    Ampicillin ≤0.03-0.125 0.06 0.125
Peptoniphilus asaccharolyticuse (n = 10)
    Telavancin 00.03-0.06 00.03 0.06
    Daptomycin ≤0.03-0.25 ≤0.03 ≤0.03
    Vancomycin 0.06-0.5 0.125 0.125
    Linezolid 0.5-1 0.5 1
    Quinupristin-dalfopristin 0.25-0.5 0.5 0.5
    Imipenem ≤0.03-≤0.03 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.06 ≤0.03 ≤0.03
    Ampicillin ≤0.03-0.125 ≤0.03 0.06
Finegoldia magnae (n = 11)
    Telavancin 00.03-0.25 0.06 0.06
    Daptomycin 0.25-4 0.5 1
    Vancomycin 0.25-1 0.25 0.5
    Linezolid 0.5-2 1 2
    Quinupristin-dalfopristin 0.25-0.5 0.25 0.5
    Imipenem ≤0.03-0.125 ≤0.03 0.125
    Piperacillin-tazobactam ≤0.03-0.5 0.125 0.5
    Ampicillin ≤0.03-0.25 0.125 0.25
Micromonas microse (n = 10)
    Telavancin 0.06-0.125 0.06 0.125
    Daptomycin 0.25-1 0.5 0.5
    Vancomycin 0.25-0.5 0.5 0.5
    Linezolid 0.5-1 0.5 1
    Quinupristin-dalfopristin 0.5-1 0.5 1
    Imipenem ≤0.03-0.125 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.25 ≤0.03 ≤0.03
    Ampicillin ≤0.03-≤0.03 ≤0.03 ≤0.03
Anaerococcus prevotiie (n = 11)
    Telavancin ≤.015-0.5 0.03 0.06
    Daptomycin ≤0.03-16 0.06 0.125
    Vancomycin 0.125-1 0.5 0.5
    Linezolid ≤0.03-2 0.5 1
    Quinupristin-dalfopristin ≤0.03-1 0.25 0.5
    Imipenem ≤0.03-0.06 ≤0.03 ≤0.03
    Piperacillin-tazobactam ≤0.03-0.125 ≤0.03 0.06
    Ampicillin ≤0.03-0.125 ≤0.03 0.06
Corynebacterium amycolatum (n = 10)
    Telavancin 0.03-0.06 0.03 0.06
    Daptomycin ≤0.03-0.125 0.06 0.06
    Vancomycin 0.25-0.5 0.5 0.5
    Linezolid 0.25-0.5 0.5 0.5
    Quinupristin-dalfopristin 0.125-0.25 0.25 0.25
    Imipenem ≤0.03->32 0.125 >32
    Piperacillin-tazobactam ≤0.03->128 4 >128
    Ampicillin 0.06->32 2 >32
Corynebacterium jeikeium (n = 11)
    Telavancin 0.03-0.06 0.06 0.06
    Daptomycin 0.125-0.5 0.25 0.5
    Vancomycin 0.5-0.5 0.5 0.5
    Linezolid 0.5-0.5 0.5 0.5
    Quinupristin-dalfopristin 0.25-1 0.25 0.5
    Imipenem 1->32 >32 >32
    Piperacillin-tazobactam 64->128 >128 >128
    Ampicillin >32->32 >32 >32
Corynebacterium groupf (n = 10)
    Telavancin ≤0.015-0.03 ≤0.015 0.03
    Daptomycin ≤0.03-0.125 0.06 0.06
    Vancomycin 0.125-0.5 0.25 0.5
    Linezolid 0.125-0.5 0.25 0.5
    Quinupristin-dalfopristin 0.125-2 0.5 0.5
    Imipenem ≤0.03->32 0.04 32
    Piperacillin-tazobactam ≤0.03->128 4 32
    Ampicillin ≤0.03->32 0.5 32
a

50% and 90%, MIC50 and MIC90, respectively.

b

A. meyeri (n = 5) and A. turicensis (n = 7).

c

E. contortum (n = 2), E. moniliforme (n = 1), E. tenue (n = 2), Pseudoramibacter alactolyticus (n = 7), and Eubacterium sp., no good fit (n = 1).

d

Includes L. acidophilus (n = 2), L. catenaforme (n = 8), L. gasseri (n = 1). L. jensenii (n = 2), L. leichmannii (n = 1), L. rhamnosus (n = 1), and L. uli (n = 1).

e

Formerly Peptostreptococcus.

f

C. pseudodiphtheriticum (n = 3), C. striatum (n = 6), and Brevibacterium sp. (n = 1).