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. 2014 Jul 15;289(34):23893–23900. doi: 10.1074/jbc.M114.557744

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Schematic models of PP-1_I activation relative to I-2 phosphorylation. I-2 inhibition (inactive) of PP-1c is relieved when Thr-72 of I-2 is phosphorylated (active). Prior phosphorylation of Ser-71 reduces phosphorylation of Thr-72 (low) and, therefore, reduces PP-1_I activity. In contrast, prior phosphorylation of Ser-86 results in increased phosphorylation of Thr-72 (high) and, therefore, increases PP-1_I activity. Under ischemic conditions, with increased PFTK1 activity and reduced CTAK1 activity, both of these phosphorylation events would lead to enhanced phosphorylation of I-2 Thr-72 (ischemia) and PP-1_I activity (very high). Stoichiometry of phosphorylation is proportional to symbol size.