TABLE 1.
Voltage dependence of activation for WT and mutant monomer and concatenated hERG1 channels
| Channel type | V0.5 | z | n |
|---|---|---|---|
| mV | |||
| WTmonomer | −28.2 ± 1.4 | 3.53 ± 0.47 | 16 |
| WT4 | −28.1 ± 1.0 | 3.64 ± 0.17 | 17 |
| R4A/R5Amonomer | −20.5 ± 1.3 | 3.81 ± 0.46 | 7 |
| WT3/(R4A/R5A)1 | −21.1 ± 1.0 | 3.52 ± 0.33 | 5 |
| (R4A/R5A)1/WT3 | −19.9 ± 1.0 | 3.96 ± 0.52 | 6 |
| (R4A/R5A)2/WT2 | −22.0 ± 1.7 | 5.19 ± 0.19 | 8 |
| (R4A/R5A)3/WT1 | −17.4 ± 0.6 | 4.87 ± 0.50 | 5 |
| (R4A/R5A)4 | −21.4 ± 0.7 | 5.20 ± 0.3.8 | 7 |
| R56Qmonomer | −22.7 ± 0.8 | 3.08 ± 0.32 | 14 |
| R56Q1/WT3 | −23.6 ± 0.7 | 3.87 ± 0.43 | 10 |
| WT2/R56Q1/WT1 | −26.8 ± 0.3 | 4.78 ± 0.15 | 8 |
| R56Q4 | −26.5 ± 0.6 | 3.32 ± 0.21 | 12 |
| F656Imonomer | −5.0 ± 2.4 | 2.60 ± 0.20 | 5 |
| F656I1/WT3 | −31.2 ± 0.5 | 2.48 ± 0.12 | 13 |
| WT2/F656I1/WT1 | −17.8 ± 0.9 | 3.94 ± 0.25 | 15 |
| WT1/F656I1/WT1/F656I1 | −13.7 ± 0.8 | 2.91 ± 0.23 | 16 |
| F656I3/WT1 | −17.9 ± 0.9 | 3.62 ± 0.08 | 8 |
| F656I4 | −18.3 ± 0.7 | 3.20 ± 0.26 | 9 |