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Insulin receptor-binding assays for biosynthetic insulin (■), synthetic human proinsulin (hpi) (●), l-SerB8-hpi (♦), l-AlaB8-hpi (▾), d-AlaB8-hpi (▴). Vertical scale indicates fractional displacement of pre-bound 125I-TyrA14-insulin on addition of wild-type or variant proinsulins at successive protein concentrations (horizontal log scale). Inferred dissociation constants are given in Table 2.
