TABLE 1.

Pathology of simulated P. falciparum infections caused by the El Limon and Santee Cooper parasite strains treated at three different time points

Time of treatment (days after start of blood-stage infection)	Avg parasitemia (no./μl)	Simulated symptoms and host responsesa
8	∼250	Typically no fever; nonspecific immunity and specific immunity not yet triggered
10	∼2,700-3,000	Fever; antibodies to some dominant EMP1 variants triggered
12	∼3,000-5,500	Severe fever; antibodies to most (if not all) EMP1 variants expressed early in the infection have been triggered

^aEMP1, P. falciparum erythrocyte membrane protein 1.