. 2004 Jun;48(6):2116–2123. doi: 10.1128/AAC.48.6.2116-2123.2004

TABLE 2.

Prevalence of recrudescent infections with >1% of parasites carrying an additional mutation compared to the infecting parasite and with treatment administered 8 days after the start of asexual infection

DHFR/DHPS genotype of infecting parasite	% of simulations with >1% of recrudescent parasites carrying an extra mutation
DHFR/DHPS genotype of infecting parasite	Three tablets achieving 100% of expected concn	Three tablets achieving 80% of expected concn	Two tablets achieving 100% of expected concn
1M/3M	0.0^a	0.0^a	0.5^a^,^b
2M/WT	0.0	0.3^b	1.7
2M/1M	1.5	2.6	4.0
2M/2M	2.6	6.5	15.6
2M/3M	10.2^a	18.6^a	20.9^a

Additional mutations can only occur in the DHFR gene.

All infections that recrudesced had >1% of parasites carrying an additional mutation compared to the infecting parasite.