Table 4.
Time after infusion, min | Baseline | NO-np
|
NAC-SNO-np-2
|
||||
---|---|---|---|---|---|---|---|
10 mg/kgBW
|
10 mg/kgBW
|
20 mg/kgBW
|
|||||
60 | 180 | 60 | 180 | 60 | 180 | ||
|
|
|
|||||
MetHb, % | -o- | -o- | 5 ± 2 | -o- | 3 ± 2 | -o- | 7 ± 3 |
|
|
|
|||||
NO3−, μM | 1.3 ± 0.3 | 2.8 ± 0.9† | 3.2 ± 0.8† | 1.6 ± 0.4†‡ | 1.7 ± 0.4† | 1.8 ± 0.5† | 2.0 ± 0.8† |
|
|
|
|||||
paO2, mmHg | 57.6 ± 7.6 | 76.2 ± 7.2† | 73.1 ± 6.7† | 59.3 ± 7.7†‡ | 58.4 ± 6.2†‡ | 62.4 ± 7.1† | 64.1 ± 7.2† |
paCO2, mmHg | 51.5 ± 5.6 | 47.8 ± 6.8† | 47.7 ± 5.8† | 49.2 ± 6.7‡ | 49.8 ± 7.1‡ | 47.5 ± 6.3 | 46.5 ± 4.7 |
|
|
|
Values are means ± SD. Baseline included all the animals. MetHb, fraction of Total Hb converted to Methemoglobin; NO3−, Nitrate; PaO2, arterial partial O2 pressure; PaCO2, arterial partial pressure of CO2.
P<0.05 compared to Baseline;
P<0.05 compared to NO-np at same concentration.