Table I.

Clinicopathological features and RNF180, DAPK1 and SFRP2 DNA methylation status in plasma samples of 57 patients with gastric cancer.

		RNF180			DAPK1			SFRP2
Parameters	n	M	U	P-value	M	U	P-value	M	U	P-value
Gender				0.137			0.928			0.446
Male	39	20	15		19	20		27	12
Female	18	13	9		9	9		14	4
Age, years				0.627			0.910			0.569
<60	24	13	11		12	12		16	8
≥60	33	20	13		16	17		25	8
Tumor size, cm3				0.018			0.705			0.784
<6	23	9	14		12	11		17	6
≥6	34	24	10		16	18		24	10
Histological type				0.025			0.940			0.769
Differentiated	14	4	10		7	7		10	4
Undifferentiated	43	29	14		21	22		31	12
TNM stage				0.002			0.647			0.683
I–II	20	6	14		9	11		15	5
III–IV	37	27	10		19	18		26	11
Lymph node metastasis				0.008			0.672			0.660
N0	24	9	15		11	13		18	6
N1–3	33	24	9		17	16		23	10
Distant metastasis				0.018			0.961			0.882
M0	50	26	24		24	26		35	15
M1	7	7	0		4	3		6	1

RNF180, ring finger protein 180; DAPK1, death-associated protein kinase 1; SFRP2, secreted frizzled-related protein 2; TNM, tumor node metastasis; M, methylated; U, unmethylated.