Table II.
Univariate and multivariate analysis of clinicopathological variables and Trop2 expression in relation to overall survival in patients with salivary adenoid cystic carcinoma.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
|
|
|
|||
| Risk factors | P-value | HR | 95% CI | P-value |
| Overall survival | ||||
| Age (≤50/>50) | 0.134 | Not included in model | ||
| Gender (Male/Female) | 0.549 | Not included in model | ||
| Histological subtype (C, S/T) | <0.001 | 2.610 | 1.159–5.876 | 0.020 |
| TNM Stage (I+II/III+IV) | 0.003 | 1.802 | 0.871–3.731 | 0.112 |
| Perineural invasion (N/P) | 0.180 | Not included in model | ||
| Local recurrence (N/P) | <0.001 | 1.427 | 0.726–2.807 | 0.302 |
| Distant metastasis (N/P) | <0.001 | 3.163 | 1.379–7.258 | 0.007 |
| TACSTD2 Expression (N/W/M/S) | <0.001 | <0.001b | ||
| TACSTD2 (W/N) | 1.521 | 0.584–3.960 | 0.390 | |
| TACSTD2 (M/N) | 3.791 | 1.436–10.010 | 0.007 | |
| TACSTD2 (S/N) | 11.193 | 3.953–31.690 | <0.001 | |
HR, hazard ratio; CI, confidence interval; N, negative; P, positive; T, tubular; C, cribriform; S, solid; W, weakly positive; M, moderately positive; S, strongly positive; HR, hazard ratio; TACSTD2, tumor-associated calcium signal transducer 2.