TABLE 2.
Maximum and minimum observed plasma voriconazole concentrations after multiple dosing
| Day (dose [mg/kg]) | Parameter | Valuea
|
||
|---|---|---|---|---|
| age group (yr)
|
All subjects | |||
| 2-<6 | 6-<12 | |||
| 4 (3) | Cmin | 166.9 (58.6, 475.5) (n = 12) | 507.4 (251.6, 1,023) (n = 14) | 303.7 (165.0, 559.1) (n = 26) |
| Cmax | 1,642 (610.3, 4,415) (n = 10) | 3,843 (2,438, 6,059) (n = 12) | 2,611 (1,582, 4,309) (n = 22) | |
| 8 (4) | Cmin | 263.3 (94.0, 737.7) (n = 11) | 696.7 (303.7, 1,598) (n = 12) | 437.5 (231.4, 827.1) (n = 23) |
| Cmax | 2,192 (1,257, 3,821) (n = 10) | 2,560 (1,381, 4,746) (n = 10) | 2,369 (1,626, 3,450) (n = 20) | |
a
Values are geometric means (nanograms per milliliter) with 95% confidence intervals (CI) in parentheses.