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Simulated pharmacokinetic data for pediatric and adult populations
| Parameter | Valuea
|
|||
|---|---|---|---|---|
| Pediatric
|
Adult
|
|||
| 3b | 4 | 3 | 4 | |
| AUCτ (ng · h/ml) | 10,670 | 14,227 | 13,855 | 38,605 |
| Cmean (ng/ml) | 889 | 1,186 | 1,155 | 3,217 |
Data are reported as medians following 6 mg/kg 12 every h on day 1 and maintenance dose 3. The values are derived from population pharmacokinetic analyses of 236 healthy volunteers.
Dosage (milligrams per kilogram).
