TABLE 5.

Patients with voriconazole dose reduced or discontinued due to AE or laboratory abnormalities

Change in voriconazole	Underlying diseasea	Day of dose reduction or discontinuation	Reason	Outcome
Discontinued	AML	13	Subdural hematoma	Died 4 days later
Discontinued	ALL	6	Fever and viral enteritis	Resolved in 3 days
Discontinued	ALL	3	Fever	Resolved in 33 days
Dose reduced then discontinued	Relapsed ALL BMT	Dose reduced on day 8, discontinued on day 11	Elevated serum creatinine (1.2 × ULN)	Died 6 days later due to bacterial sepsis and meningitisb
Discontinued	Fanconi's anemia; autoimmune hepatitis	7	Elevated AST and ALT (10 × ULN)	AST and ALT normalized in 34 days
Dose reduced	ALL; BMT	14	Abnormal renal function and elevated serum creatinine	Resolved in 27 days

^aALL, acute lymphoblastic leukemia; AML, acute myelogenous leukemia; BMT, blood and marrow transplantation.

^bStomatococcus mucilaginosus.