TABLE 6.
Clinically significant elevations in serum bilirubin, hepatic transaminases, ALKP, and serum creatinine
| Biochemical parameter | Criterion for elevation (ULN) | No. of patients receiving loading dose followed by 3 mg/kg (n/N)a | No. of patients receiving 4 mg/kg (n/N) |
|---|---|---|---|
| Bilirubin | >1.5 | 1/27 | 5/27 |
| ALT | >3 | 2/27 | 3/27 |
| AST | >3 | 1/27 | 1/27 |
| ALKP | >3 | 0/25 | 0/26 |
| Creatinine | >1.3 | 0/26 | 0/27 |
a
n, number of patients with abnormal values; N, number of patients studied and for whom serial laboratory values were recorded.