TABLE 4.
Relevant clinical data on efficacy of antibiotic treatment of Bartonella-related infectionsa
| Disease | Drug | Duration | No. of patients
|
Reference | ||
|---|---|---|---|---|---|---|
| Total | Cured | Relapse | ||||
| Chronic bacteremia | No treatment | 9 | 2 | 7 | 36 | |
| Gentamicin + doxycycline | 14 + 28 days | 7 | 7 | 0 | 36 | |
| Amoxicillin | 5 days | 1 | 0 | 1 | 65 | |
| Ceftriaxone | 10 days | 2 | 2 | 0 | 65 | |
| BA-PH | Erythromycin | 2-12 wk | 8 | 5 | 3 | 38 |
| 2-4 mo | 4 | 3 | 1 | 55 | ||
| NI | 1 | 1 | 0 | 102 | ||
| 4-6 wk | 1 | 1 | 0 | 105 | ||
| 28-56 days | 10 | 8 | 2 | 75 | ||
| Clarithromycin | 8 wk | 1 | 1 | 0 | 38 | |
| Tetracycline | 8 wk | 1 | 1 | 0 | 38 | |
| 7-56 days | 3 | 2 | 1 | 75 | ||
| Penicillin G | NI | 2 | 0 | 2 | 54 | |
| TMP-SMX | 14 days | 3 | 0 | 3 | 75 | |
| Endocarditis | Aminoglycoside > 15 days with or without another antibiotic | 2-6 wk | 82 | 74 | 8 | 83 |
| Other regimens | 6 wk | 19 | 13 | 4 | 83 | |
| Carrion's disease | ||||||
| Oroya fever | Chloramphenicol with or without another antibiotic | 10-14 days | 65 | 62 | 3 | 66 |
| No treatment | 16 | 2 | 14 | 39 | ||
| Chloramphenicol | 7-14 days | 10 | 10 | 0 | 39 | |
| Verruga peruana | Rifampin | 10 days | 46 | 37 | 9 | 66 |
| Streptomycin | 10 days | 9 | 5 | 4 | 66 | |
Abbreviations: NI, duration of treatment not indicated; TMP-SMX, trimethoprim-sulfamethoxazole.