FIG. 2.

Mechanism of anti-HSV activity. Synchronized infections were conducted as described in Materials and Methods. Each panel shows a dose-response to the indicated compound when the compound was added during the 4°C binding period (binding; hatched bars), at the time of temperature shift (penetration; open bars), or immediately postentry (black bars). The results are presented as the PFU formed in the presence of drug as a percentage of the PFU formed in the presence of medium and are the means ± standard deviations of three independent experiments performed in duplicate.